Welcome to the Best Hotel in Beaufort, SC You'll discover Southern hospitality and charm at the Holiday Inn Hotel Beaufort , nestled in the heart of South Carolina's Lowcountry. Our location is just off Highway 170 and Route 21 and overlooks the Beaufort River in Beaufort, SC, an antebellum seaside town that is steeped in history and beauty. Our hotel in Beaufort, SC welcomes the family and friends attending the year-round graduation ceremonies at the Parris Island Marine Recruitment Center , six miles from our hotel. Beaufort's downtown is rich in history and just one mile away. You can take a horse-drawn buggy tour with a professional guide to discover the secrets of historic Beaufort. And it's easy to spend a day on the inter-coastal waterway or island hop to Seabrook Island or Hilton Head Island, as both are just a half-hour away. Corporate guests appreciate that our Beaufort hotel is near Parris Island. The University of South Carolina - Beaufort is two miles and Beaufort Memorial Hospital is just minutes from our accommodations. Guests lodging at our Beaufort hotel can relax by the indoor pool and whirlpool or enjoy a workout in the Fitness Center. A 24-hour Business Center allows you to catch up on work or check your email. The Holiday Inn Hotel Beaufort welcomes you with top-notch service, Southern hospitality and an award-winning attitude. Check out our great Beaufort hotel deals and rates today.