Welcome to the Holiday Inn Express® Florence Hotel This premiere Holiday Inn Express® hotel is conveniently situated on Hwy 327 and I-95 in Florence, SC. Our hotel's location in the suburbs takes you away from the city's hustle and bustle while keeping you close to important sites like Florence Regional Airport. When you're looking for convenient business hotels in Florence, the Holiday Inn Express® hotel is a perfect choice. We're surrounded by companies, including Angus-Palm, Beneteau, Blanchard Machinery, DuPont, FedEx, HJ Heinz, Honda, IFH, Johnson Controls, Monster, NuCor Steel, Pepsi, Roche Carolina, Smurfit-Stone and QVC. We're also just minutes from Francis Marion University. Professional guests can host events in our 60-person meeting room or utilize the services in our 24-hour business center. Leisure guests love the convenience of our hotel's Florence locale. Close to numerous local highlights, including the Country Club of SC, Darlington Raceway and Freedom Florence, we're ideal for traveling families. Whether business or pleasure brings you to Florence, SC, our hotel's choice amenities satisfy your needs. Connect to friends or family with our free Internet access, enjoy our fitness center, browse through our convenient sundry shop and relax in our heated, indoor pool. You'll have a great start to each day with our Express Start Breakfast bar, featuring hot items, signature cinnamon rolls and coffee.